In the battle against obesity, many individuals turn to various methods and medications to aid in their weight loss journey. One such medication that has gained popularity is Orlistat. But does Orlistat actually burn existing fat? In this comprehensive article, we will delve into the scientific evidence and explore the mechanism of action, recommended use, and potential benefits of Orlistat in the treatment of obesity.
Understanding Orlistat
Orlistat, also known by its brand name Xenical, is a non-centrally acting anti-obesity agent that works locally in the gastrointestinal tract to inhibit pancreatic and gastric lipases. These enzymes play a vital role in the digestion of long-chain triglycerides. By inhibiting these enzymes, Orlistat prevents the absorption of dietary fat, leading to a reduction in calorie intake and potential weight loss. (1)
Mode of Action
Orlistat is a synthetic derivative of lipstatin, a naturally occurring lipase inhibitor produced by Streptomyces toxytricini. When Orlistat is consumed, it forms a covalent bond with the active serine residue site of gastric and pancreatic lipases, rendering them inactive. As a result, the hydrolysis of dietary fat into absorbable free fatty acids and monoglycerides is hindered. (2)
The Efficacy of Orlistat
Numerous studies have examined the efficacy of Orlistat in promoting weight loss. In randomized controlled trials, Orlistat has been shown to be significantly more effective than a placebo in reducing body weight. The weight loss achieved with Orlistat is modest but clinically significant, with studies indicating an average weight loss of approximately 2.7 kg (5.95 lbs) more than diet alone.
Additionally, Orlistat has demonstrated efficacy in improving cardiovascular risk profiles. Modest weight loss of 5% to 10% in obese individuals has been associated with improvements in cardiovascular risk factors and a reduced incidence of type 2 diabetes. Studies have shown that Orlistat not only aids in weight loss but also improves glycaemic parameters in obese adults with type 2 diabetes mellitus. (3)
Recommendations for Use
In adults, the recommended dose of Orlistat is one 120 mg capsule with each main meal. It is advised to take the capsules immediately before, during, or up to 1 hour after the meal. To maximize the efficacy of Orlistat, it is important to follow a well-balanced, mildly hypocaloric diet that contains approximately 30% of calories from fat. Distributing the daily intake of fat, carbohydrate, and protein evenly over three main meals is recommended.
It is worth noting that gastrointestinal side effects, such as oily stools and increased frequency of bowel movements, may occur when Orlistat is consumed with a high-fat meal. Therefore, it is advisable to reduce fat intake while using Orlistat to minimize these side effects. (4)
Safety and Tolerability
Orlistat is generally well tolerated by adults and adolescents. Adverse effects experienced by individuals taking Orlistat are typically mild and transient, with most resolving within a few weeks of treatment. The most common adverse events are related to the gastrointestinal tract, including oily spotting, flatus with discharge, and fecal urgency.
It is important to note that Orlistat may interact with certain medications. The absorption of ciclosporin and amiodarone may be affected when coadministered with Orlistat. In addition, the bioavailability of oral contraceptives may be reduced in women who experience severe diarrhea while taking Orlistat. (5)
The Role of Orlistat in Obesity-related Comorbidities
Obesity is often associated with various comorbid conditions, such as type 2 diabetes mellitus and the metabolic syndrome. The use of Orlistat in the management of these conditions has shown promising results. Studies have demonstrated that Orlistat improves glycaemic parameters in obese adults with type 2 diabetes, leading to a reduction in the need for antidiabetic medication or an improvement in glucose tolerance.
Furthermore, Orlistat has been shown to be effective in reducing cardiovascular risk factors, irrespective of diabetic status or the presence of metabolic syndrome. It has the potential to improve factors involved in the pathogenesis of cardiovascular disease, contributing to overall cardiovascular health.
Orlistat and Weight Maintenance
Weight maintenance is a crucial aspect of any weight management strategy. Orlistat has shown efficacy in maintaining weight loss in both short-term and long-term studies. In a four-year double-blind, randomized, placebo-controlled trial, Orlistat was found to significantly reduce weight regain compared to placebo. Additionally, a study focusing on weight maintenance after weight loss with a very low-energy diet demonstrated significantly reduced weight regain with Orlistat.
It is important to note that attrition rates in clinical practice may be higher than those observed in clinical trials. Factors such as cost and side effects may contribute to the discontinuation of Orlistat treatment. However, it is worth mentioning that several pharmacoeconomic studies have shown that Orlistat is a cost-effective treatment for obese patients with or without type 2 diabetes.
Orlistat and Adolescents
While most of the available literature focuses on adults, there have been some studies evaluating the impact of Orlistat on weight loss in adolescents. A multi-center trial involving obese adolescents showed that Orlistat led to a decrease in BMI compared to placebo. However, another study found that Orlistat did not significantly reduce BMI in adolescents after six months of treatment. Further research is needed to determine the efficacy and safety of Orlistat in this population.
Thermogenic Fat Burner Options
In the world of weight loss supplements, finding the right thermogenic fat burner can be a daunting task. With so many options available, it’s important to understand the key ingredients and unique features of each product. That’s why we’re pitting Alphamine by PEScience against Roxylean by BPI Sports, B4 by ALRI, Hyperdrive 3.0 by Finaflex, and PX by Finaflex in the ultimate fat burner showdown. Join us as we dive deep into the world of thermogenic supplements and uncover the secrets behind these powerhouse products.
Alphamine: Energize Your Weight Loss Journey
Alphamine is a caffeinated thermogenic supplement that aims to provide a boost of energy while helping you work towards your weight loss goals. With its unique blend of key ingredients like theanine, 6-Paradol, Olive Leaf Extract, and BioPQQ, Alphamine supports an increase in metabolic rate, thermogenesis, and focus. Let’s take a closer look at the key ingredients that make PEScience Alphamine stand out from the crowd.
Theanine: Unwind and Focus
One of the key ingredients in Alphamine is theanine, an amino acid known for its ability to promote relaxation and reduce stress. Studies have shown that theanine, when combined with caffeine, can enhance focus and improve cognitive performance (1). So not only does Alphamine provide a boost of energy, but it also helps you stay sharp and focused throughout the day.
Olive Leaf Extract: Nature’s Antioxidant Powerhouse
Another standout ingredient in Alphamine is Olive Leaf Extract. Packed with antioxidants and anti-inflammatory compounds like oleuropein and hydroxytyrosol, Olive Leaf Extract offers numerous health benefits. Research suggests that it may help regulate weight gain, suppress appetite, and even support the expression of genes related to weight management (2). By incorporating Olive Leaf Extract into its formula, Alphamine sets itself apart from other weight loss supplements on the market.
Caffeine: The Ultimate Performance Enhancer
No thermogenic fat burner would be complete without caffeine. Known for its ability to improve energy levels, mental alertness, and physical performance, caffeine is a staple ingredient in weight loss supplements and is widely used by athletes (3). Alphamine harnesses the power of caffeine anhydrous and dicaffeine malate (infinergy) to provide a sustained release of energy, helping you power through your workouts and stay focused on your weight loss journey.
Supplement Facts: What’s Inside Alphamine?
To give you a better understanding of what you’re putting into your body, let’s take a look at the supplement facts of Alphamine:
| Serving Size | 1 Capsule |
|---|---|
| Serving Per Container | 60 |
| Key Ingredients | Amount Per Serving |
|---|---|
| Caffeine | 125mg* |
| Theanine | 100mg* |
| oleaBURN | 80mg* |
| Olive Leaf Extract (providing 20mg oleuropein), Olive Leaf Extract (providing 5mg hydroxytyrosol) | |
| Aframomum Melegueta (Seed) Extract (12% 6-paradol) | 15mg* |
| Pyrroloquinoline Quinone (BioPQQ) | 5mg* |
*Daily Value Not Established
Other Ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, FD&C Blue #1, FD&C Red #40.
Directions: Take 1 capsule 1-2 times daily. Not for individuals sensitive to caffeine. Do not exceed 2 capsules per day. Consume at least 125 Fl. Oz. of liquid per day for men and 91 Fl. Oz. of liquid per day for women while taking this product.
Warnings: Please consult with your physician before using this product, especially if you are using any prescription or over the counter medication or if you have any pre-existing medical condition. This product contains caffeine and should not be taken by individuals wishing to eliminate this ingredient from their diet. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Do not take if pregnant or nursing. Do not use if safety seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
Roxylean: Unleash the Power of Goldenseal and Citrus Limon
Now, let’s turn our attention to Roxylean by BPI Sports. This all-in-one diet formula combines the power of goldenseal, citrus limon, and other fat-burning ingredients to support weight loss, appetite control, energy, and well-being. What sets Roxylean apart from other fat burners on the market? Let’s find out.
Goldenseal: The Water Eliminator
One of the unique ingredients in Roxylean fat burner is goldenseal. Known for its ability to support the removal of excess water and aid in the elimination of toxins, goldenseal can play a crucial role in weight loss efforts. By regulating water retention, goldenseal may help reduce bloating and promote a leaner physique.
Citrus Limon: A Natural Diuretic and Appetite Suppressant
Citrus limon, commonly known as lemon, is another key ingredient in Roxylean. Not only does it provide a refreshing taste, but it also offers several weight loss benefits. Citrus limon acts as a natural diuretic, helping to decrease bloating and support weight loss. Additionally, it may help control appetite, making it easier to stick to your diet and resist cravings.
Caffeine and Yohimbine: A Powerful Fat-Burning Duo
Roxylean harnesses the power of caffeine and yohimbine to boost thermogenesis and promote fat loss. Caffeine, a well-known stimulant, increases energy levels and enhances mental focus. Yohimbine, on the other hand, blocks alpha-2 adrenergic receptors in fat cells, leading to greater fat loss (1) (2). By combining these two ingredients, Roxylean provides a potent fat-burning combination.
Supplement Facts: What’s Inside Roxylean?
Let’s take a closer look at the supplement facts of Roxylean:
| Serving Size | 1 Capsule |
|---|---|
| Serving Per Container | 60 |
| Key Ingredients | Amount Per Serving |
|---|---|
| Thiamin | 185 mg (Vitamin B1, as thiamin HCl and thiamin disulfide) |
| Niacin | 30 mg |
| ROXYLEAN Blend (Proprietary): | |
| Caffeine (as caffeine anhydrous) | |
| Lemon (Citrus limon) (whole) | |
| Adhatoda (Adhatoda vasica) (leaf) | |
| Yohimbe (Pausinystalia yohimbe) (bark) | |
| Goldenseal (Hydrastis canadensis) (root) | |
| White willow [(Salix alba) as Salicin, (root)] | |
| Chinese skullcap (Scutellaria baicalensis) (root) | |
| Rauwolfia (Rauwolfia serpentina) (root/rhizome) |
Other Ingredients: Gelatin, magnesium stearate, Capsicum annuum (fruit), FD&C Blue No. 1, FD&C Red No. 3, FD&C Red No. 40, FD&C Yellow No. 6 and titanium dioxide.
Directions: Take one (1) capsule daily, in the morning on an empty stomach before food, or as directed by a qualified healthcare practitioner. Due to the extreme potential strength of this product, do not exceed more than one (1) capsule per day.
Warnings: Not intended for use by persons under age 18. Do not exceed recommended dose. Do not take for more than eight (8) consecutive weeks. Do not use if you are pregnant, nursing, or allergic or contraindicated to aspirin. Discontinue use two weeks prior to surgery or if upset stomach occurs. Get the consent of a licensed physician before using this product, especially if you are taking medication, have a medical condition, or are thinking about becoming pregnant. KEEP THIS PRODUCT AND ALL SUPPLEMENTS OUT OF THE REACH OF CHILDREN.
Caffeine warning: The recommended serving of this product contains approximately as much caffeine as three cups of coffee. Do not consume caffeine, or combine with synephrine, including but not limited to coffee, tea, soda, and other dietary supplements or medications containing phenylephrine or caffeine. Too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally rapid heartbeat. Discontinue use if you experience dizziness, severe headache, rapid heartbeat, or shortness of breath.
Caution: Roxylean contains the B vitamin niacin. Niacin may cause temporary flushing, tingling, skin reddening, and sensations of heat, especially if taken on an empty stomach. This is a common reaction.
B4: The Perfect Pre-Workout Weight Loss Supplement
Next up, we have B4 by BPI Sports. This unique weight loss support supplement combines the benefits of a pre-workout formula with the power of weight loss ingredients, all thanks to its star ingredient, dendrobium. Let’s explore what sets B4 apart from the competition.
Dendrobium: The DMAA Alternative
One of the key ingredients in B4 BPI Sports is dendrobium. Used in Chinese medicine for years, dendrobium is believed to be a suitable substitute for DMAA in pre-workout and weight loss supplements. While the exact mechanisms are still being studied, dendrobium is thought to enhance energy levels and improve physical performance.
Quercetin: Fuel Your Workouts
B4 also includes quercetin, a powerful antioxidant with anti-inflammatory properties. Research suggests that quercetin may support harder training and combat metabolic fatigue, allowing you to push through your workouts and reach new levels of performance (3). By including quercetin in its formula, B4 aims to provide the fuel you need to maximize your training sessions.
Yohimbine: Unlock Greater Fat Loss
Yohimbine, another key ingredient in B4, has been shown to support greater fat loss by blocking alpha-2 adrenergic receptors in fat cells (1). By inhibiting these receptors, yohimbine may promote the breakdown of stored fat and enhance weight loss efforts. Combined with the other ingredients in B4, yohimbine aims to help you achieve your fat loss goals.
Conclusion
In conclusion, Orlistat is a medication that inhibits the absorption of dietary fat, leading to modest weight loss when used in conjunction with a well-balanced diet. It has demonstrated efficacy in promoting weight loss, improving cardiovascular risk profiles, and managing obesity-related comorbidities such as type 2 diabetes. Orlistat is generally well tolerated, with mild gastrointestinal side effects being the most commonly reported adverse events.
While Orlistat can be an effective tool in the management of obesity, it is important to remember that weight loss should be approached holistically, incorporating healthy eating habits, regular physical activity, and behavioral changes. If you are considering the use of Orlistat, it is advisable to consult with a healthcare professional to determine if it is suitable for your individual needs and to ensure proper monitoring of its effects.
