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Androdiol Hi Tech Buy Legal Androstene Prohormone Testosterone

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Model: hitech22
  • Manufactured by: Hi Tech Pharmaceuticals

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Androdiol by Hi Tech Pharmaceuticals delivers one of the most powerful legal prohormones plus testosterone boosters available to buy today. Racer Ephedra offers the best prohormones at the lowest prices with fast shipping all online. Buy Androdiol Legal Prohormone The key ingredient in...

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Androdiol by Hi Tech Pharmaceuticals delivers one of the most powerful legal prohormones plus testosterone boosters available to buy today. Racer Ephedra offers the best prohormones at the lowest prices with fast shipping all online.

Buy Androdiol Legal Prohormone

The key ingredient in Androdiol is 4-androstene-3b-ol, 17-one that is an effective and legal prohormone compound. Hi Tech has improved the delivery through the Cyclosome Deliver System allowing for high bioavailability. What makes Androdiol different than other Andro supplements is the bodybuilding compounds don't aromatize to estrogen and doesn’t convert to DHT. According to Hi Tech the Cyclosome Technology allows for almost complete absorption for its prohormone compounds. (1)

Hi Tech Pharmaceuticals has become the leader in prohormone and testosterone boosting compounds. With legal formulas that work without the side effects associated with past prohormones, Hi Tech has allowed bodybuilders to find hard core products to maximize their results.

What makes Hi Tech prohormones different is the Cyclosome technology which is a water soluble prohormone cyclodextrin complex in liposomes. This revolutionary system allows for the prohormone compounds to pass through the liver intact for maximum absorption. Most prohormone supplements are destroyed by the liver and never make it to being effective.

Active Ingredients

  1. 4-androsten-3β-ol-17-one - Boost your performance with 4-androsten-3β-ol-17-one, a potent testosterone enhancer. Experience rapid muscle gains and increased strength. Perfect for athletes seeking an edge. Note: May affect steroid test results.

Alternative Products

  1. Andriol - Elevate vitality and strength with Andriol by Hi-Tech Pharmaceuticals. This patented testosterone aid boosts mood, libido, and muscle mass using the unique 4-androsten-3β-ol-17-one Undecanoate compound. Enjoy year-round benefits with enhanced bioavailability for sustained testosterone levels. Transform your life today!

Hormone Regulation and Androgens

In the realm of hormone regulation, androgens play a vital role in various biological processes. These "rejuvenating hormones" are primarily associated with male phenotype development and the maintenance of male physiology. However, recent research has shed light on the significance of androgens in female physiological functions as well. Two key natural androgens, testosterone (T) and 5α-dihydrotestosterone (DHT), have been extensively studied for their effects on reproductive and non-reproductive target tissues.

But what about the precursors to these potent androgens? Enter androstene prohormones, specifically androstenedione (A-dione) and 4-androsten-3β,17β-diol (A-diol). These prohormones, commonly referred to as "Andro" prohormones, have garnered attention for their potential role in hormone regulation. While A-dione serves as an immediate precursor to T, A-diol acts as a substrate for the conversion of A-dione to T through the action of 17β-hydroxysteroid dehydrogenase. (1)

The Complexity of Androgen Receptor Activation

To understand the potential of androstene prohormones, it is essential to delve into the mechanisms of androgen receptor (AR) activation. The AR, a member of the steroid receptor subfamily of the nuclear receptor superfamily, acts as a ligand-inducible transcription factor. Upon ligand binding, the AR dissociates from its chaperones and initiates a cascade of events leading to transcriptional regulation of target genes. The liganded receptor can also interact with other transcription factors, functioning as a ligand-regulated co-factor.

Partial Agonism and Antagonism of Androstene Prohormones

Recent studies have shed light on the partial agonistic and antagonistic properties of androstene prohormones. Researchers have characterized the activities of A-dione and A-diol in various cell lines, including MDA-MB-453 (MDA) and LNCaP cells. In these cell-based transcription assays, A-dione and A-diol demonstrated partial agonist activities on the transfected mouse mammary tumor virus (MMTV) and endogenous prostate-specific antigen (PSA) promoters. These prohormones exhibited partial agonism in inducing PSA production in LNCaP cells. (2)

Interestingly, A-dione and A-diol also displayed antagonistic properties, especially in the context of DHT or R1881-induced PSA expression. These prohormones significantly suppressed the induction of PSA by DHT or R1881, suggesting their potential as modulators of androgen signaling pathways. Furthermore, A-dione and A-diol induced LNCaP cell proliferation while demonstrating only mild inhibition of DHT-enhanced cell growth. These findings highlight the complex interplay between androstene prohormones and AR signaling.

Binding Affinity and Transcriptional Regulation

To further elucidate the molecular mechanisms underlying the actions of androstene prohormones, researchers investigated their binding affinity to AR. The binding assays revealed that A-dione and A-diol bound to full-length endogenous AR from MDA or LNCaP cells with affinities ranging from 30 to 70 nM. However, their binding to the expressed ligand-binding domain (LBD) of AR was comparatively weaker, emphasizing the importance of the AR aporeceptor complex in accurately assessing their binding affinities. (3)

Unraveling the Potential of Androstene Prohormones

The characterization of androstene prohormones, A-dione, and A-diol, has provided valuable insights into their potential as ligands for AR. While they exhibit partial agonist/antagonist activities in cell-based transcription assays, their binding affinities are most accurately assessed through the AR aporeceptor complex. These findings highlight the multifaceted nature of androgen signaling and the intricate regulation of AR-mediated transcriptional activity.

Future Perspectives and Therapeutic Implications

The discovery of androstene prohormones as ligands for AR opens up exciting possibilities for the development of novel therapeutic strategies. The ability of these prohormones to modulate AR activity without the adverse effects associated with traditional androgen therapies presents a promising avenue for further research. Selective androgen receptor modulators (SARMs) that exhibit tissue-specific agonist and antagonist activities have already shown promise in preclinical models. It remains to be seen whether androstene prohormones can be harnessed to achieve similar selective modulation of AR signaling.

Conclusion

Androstene prohormones, A-dione, and A-diol, have emerged as intriguing players in the complex world of androgen regulation. Their partial agonist/antagonist activities and binding affinities to AR underscore their potential as modulators of androgen signaling pathways. While further research is needed to unlock their full therapeutic potential, these prohormones offer a promising alternative to traditional androgen therapies. As our understanding of androgen receptor activation and transcriptional regulation continues to evolve, the role of androstene prohormones in hormone regulation may become increasingly significant.

Through the exploration of androstene prohormones, researchers are paving the way for a deeper understanding of hormone regulation and the development of more targeted therapeutic interventions. As we unravel the complexities of androgen signaling, the potential of these natural steroids to unlock new possibilities in the field of hormone therapy becomes ever more apparent.

SUGGESTED USE

Take 2 tablets spread out during the day. Do not exceed 4 tablets daily.

Supplement Facts

Serving Size: 1 tablet
Servings Per Container: 60

4-Androstene-3b-ol, 17-one Decanoate 75mg, 5a-Hydroxy Laxogenin Acetate 50mg

Disclaimer: The information provided in this article is for informational purposes only and should not be considered as medical advice. Always consult with a qualified healthcare professional before making any changes to your hormone therapy regimen.

Landon M.

I like it because it's giving me results. Big strength gains and fuller muscles.

Marco J.

Great product. Started noticing a difference in first week of taking. Had some strength increase and muscles feel more full during workouts. Will buy more when finish this bottle.

Jayson S.

First time using this not sure what to expect. Some strength increase and good workouts. Hoping for more results in the next week.