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4-androsten-3β-ol-17-one

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buy 4-androsten-3β-ol-17-one

Elevate your athletic performance with 4-androsten-3β-ol-17-one, the ultimate supplement designed to enhance your natural steroid profiles and boost testosterone levels. This powerful compound is engineered for athletes who seek a competitive edge, ensuring optimal performance and faster recovery times.

Key Features and Benefits:

  1. Enhanced Testosterone Levels: Experience a significant increase in testosterone, which promotes muscle growth, strength, and overall athletic performance. Our advanced formulation ensures that testosterone concentrations rise swiftly, providing noticeable results.

  2. Rapid Absorption and Effectiveness: Unlike traditional supplements, 4-androsten-3β-ol-17-one is optimized for maximum absorption and bioavailability. This means you’ll feel the effects faster, allowing you to push through intense workouts more effectively.

  3. Temporary Boost without Long-Term Disruption: Enjoy the benefits of increased testosterone without long-term disruptions. Our studies show that testosterone levels normalize within 24 hours post-administration, making this supplement ideal for short-term performance enhancement.

  4. Optimized for All Athletes: Whether you're a seasoned bodybuilder or an aspiring athlete, this supplement is designed to suit all fitness levels. It's particularly effective due to its unique metabolic pathway which ensures higher efficacy compared to other over-the-counter options.

Unique Selling Points:

  1. Fast Acting: The rapid metabolism of 4-androsten-3β-ol-17-one means you get quick results, perfect for those needing an immediate performance boost.

  2. Safe and Detectable: Our product is formulated to ensure safety and compliance with athletic testing standards. Users can confidently take our supplement without fear of long-term adverse effects on steroid profiles.

  3. Scientifically Backed: Our formulation is grounded in extensive research and human excretion studies, ensuring you receive a product that is both effective and reliable.

Unlock new levels of performance with 4-androsten-3β-ol-17-one. Whether you're aiming to break your personal bests or enhance your daily workouts, this supplement offers the support you need to achieve your goals.

Experience the difference today – add 4-androsten-3β-ol-17-one to your regimen and take the first step towards unparalleled athletic excellence!

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  1. Andriol - Boost your vitality with Andriol by Hi-Tech Pharmaceuticals. This patented testosterone aid elevates mood, libido, and muscle mass. Unique 4-androsten-3β-ol-17-one Undecanoate ensures maximum bioavailability for year-round use. Experience unmatched strength gains and overall wellness with Andriol's advanced formula.
  2. Superdrol - Experience rapid muscle gains and enhanced performance with Superdrol. This potent anabolic steroid promotes protein synthesis, boosts strength, and improves endurance. Ideal for serious bodybuilders and athletes seeking exceptional results. Unleash your potential today!
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Clinical DHEA

Unlock the potential of precise hormone quantification with 4-androsten-3β-ol-17-one Clinical DHEA, a cutting-edge solution designed for unparalleled accuracy in serum analysis. This advanced DHEA quantification method leverages the power of tandem mass spectrometry coupled with liquid chromatography, ensuring highly accurate and reliable results even at low concentration levels.

What sets 4-androsten-3β-ol-17-one Clinical DHEA apart is its innovative use of DHEA-D5, a stable isotope-labeled analogue of DHEA. By adding measured amounts of DHEA-D5 to real serum from healthy subjects, the method eliminates cross-reactivity with endogenous interferences that typically compromise accuracy in immunoassay-based methods. This ensures that every measurement is precise, facilitating consistent and dependable hormone monitoring.

With a lower limit of detection (LLOD) of 0.09 ng/mL and a lower limit of quantification (LLOQ) of 0.23 ng/mL, this method demonstrates exceptional sensitivity and selectivity. These performance metrics make it suitable for routine use in clinical laboratories, providing professionals with a reliable tool to achieve accurate results consistently.

Key benefits include:

  1. Enhanced Accuracy: Overcomes common pitfalls in traditional immunoassay methods by using DHEA-D5.
  2. High Sensitivity: Detects DHEA levels as low as 0.09 ng/mL.
  3. Routine Usability: Designed for regular application in clinical settings due to its robust performance metrics.

Elevate your laboratory’s capabilities with 4-androsten-3β-ol-17-one Clinical DHEA and experience the future of hormone quantification.

Neurosteroids as Endogenous Inhibitors

Discover the remarkable benefits of Neurosteroids as Endogenous Inhibitors, a cutting-edge supplement designed to harness the natural protective power of neurosteroids like dehydroepiandrosterone (DHEA), its sulfate ester DHEAS, and allopregnanolone (Allo). Produced in both the adrenal glands and the brain, these potent compounds play a crucial role in safeguarding your central nervous system (CNS) against toxic agents, particularly as we age.

As we grow older, the production and serum levels of these vital neurosteroids diminish, leading to age-related neuronal dysfunction and degeneration. This unique product aims to counteract this decline by delivering an optimal dosage that has been scientifically proven to protect CNS neurons. DHEA(S) defends hippocampal neurons from NMDA-induced excitotoxicity in rats, while Allo offers similar protection for human neurons.

Key Features:

  1. Neuronal Protection: Shields CNS neurons against harmful agents, reducing the risk of neuronal degeneration.
  2. Sympathetic Nervous System Support: Protects chromaffin cells and sympathoadrenal PC12 cells from apoptosis induced by serum deprivation.
  3. Prosurvival Effect: Time- and dose-dependent effectiveness with EC50 values of 1.8 nM (DHEA), 1.1 nM (DHEAS), and 1.5 nM (Allo).
  4. Receptor-Independent Mechanism: The prosurvival effects bypass typical receptor pathways, utilizing specific G-protein-coupled membrane binding sites.
  5. Activation of Protective Pathways: Enhances expression of antiapoptotic Bcl-2 proteins, CREB, NF-κB transcription factors, and prosurvival kinase PKCα/β.
  6. Catecholamine Biosynthesis Stimulation: Promotes neuroprotective catecholamine synthesis and release through direct transcriptional effects on tyrosine hydroxylase.

With Neurosteroids as Endogenous Inhibitors, you can help maintain your brain's natural defenses against age-related challenges. Supporting your neuronal health has never been easier or more effective.

Elevate your cognitive well-being today—embrace the power of neuroprotection with our advanced formula!

Dehydroepiandrosterone and allopregnanolone

Unlock the power of cellular protection with Dehydroepiandrosterone (DHEA) and Allopregnanolone (Allo), specially formulated to safeguard your cells from ischemia and excitotoxicity-induced injury. These neuroactive steroids, produced by the CNS and adrenals, play a pivotal role in maintaining the health of hippocampal and cortical neurons. But their benefits extend beyond the brain, offering vital protection to the adrenal medulla, a crucial part of your sympathetic nervous system.

Key Features:

  1. Neuroprotective Benefits: DHEA, DHEAS, and Allo provide robust protection against neuron damage in the hippocampus and cortex.
  2. Adrenal Medulla Support: These compounds also shield adrenal medulla cells from apoptosis due to serum deprivation.
  3. Specific Efficacy: The protective effects are structure-specific, with optimal performance by 3β-OH-Δ5 for androstenes and 3α-OH for pregnanes.
  4. Independent Mechanisms: The prosurvival effects are not reliant on NMDA, GABAA, sigma1, or estrogen receptors, making them versatile in their protective action.
  5. Antiapoptotic Activation: DHEA(S) and Allo activate critical pathways like cAMP response element-binding protein and NF-κB to boost antiapoptotic Bcl-2 protein expression.
  6. PKCα/β Activation: These compounds also trigger PKCα/β kinase, enhancing posttranslational activation of Bcl-2 protein.

Specifications:

  1. EC50 Values: Effective concentrations at 1.8 nM for DHEA, 1.1 nM for DHEAS, and 1.5 nM for Allo ensure potent protection.
  2. Proven Science: Backed by studies on rat chromaffin cells and PC12 cell lines.

Declining levels of DHEA(S) and Allo during aging or stress can leave your adrenal medulla vulnerable. Reinforce your body's natural defenses with our advanced formulation of Dehydroepiandrosterone and Allopregnanolone. Experience a science-backed approach to cellular survival and well-being.

Serum Testosterone Clinical Measurement

Development and evaluation of a candidate reference measurement procedure for the determination of testosterone in human serum using isotope dilution liquid chromatography/tandem mass spectrometry. This cutting-edge procedure has been meticulously developed and critically evaluated to provide accurate and reliable measurements of total testosterone in human serum.

The method involves the use of isotope dilution (ID) combined with liquid chromatography/tandem mass spectrometry (LC/MS/MS) to extract both endogenous testosterone and its internal standard (testosterone-d 3) from the serum matrix. A combination of solid-phase extraction and liquid-liquid extraction is employed prior to reversed-phase LC/MS/MS to ensure optimal accuracy.

To evaluate accuracy, a recovery study was conducted using testosterone-spiked serum. The recovery of the added testosterone consistently ranged from 100.0 to 100.3%, showcasing the method's precision. This technique was successfully applied to frozen serum samples from three individual donors, demonstrating its versatility in different scenarios.

Notably, this reference measurement procedure exhibits exceptional repeatability and intermediate precision, with within-set coefficients of variation (CVs) ranging from 0.1 to 1.0% and between-set CVs from 0.1 to 0.5% for both female and male serum materials. The method also boasts excellent linearity, ensuring consistent and reliable results.

With a detection limit as low as 2 pg of testosterone in serum, this procedure sets a new standard for sensitivity in testosterone measurement. Moreover, it has been rigorously tested against structural analogs and testosterone metabolites, proving its high selectivity and minimal interference.

This well-characterized LC/MS/MS method serves as a reference measurement procedure, providing an accuracy base against which routine methods for testosterone can be compared. It establishes measurement traceability and guarantees a standard of higher order.

References

Victor P. Uralets, Paul A. Gillette, Over-the-Counter Anabolic Steroids 4-Androsten-3,17-dione; 4-Androsten-3β,17β-diol; and 19-nor-4-Androsten-3,17-dione: Excretion Studies in Men, Journal of Analytical Toxicology, Volume 23, Issue 5, September 1999, Pages 357–366, https://doi.org/10.1093/jat/23.5.357

Campi, B., Frascarelli, S., Pietri, E. et al. Quantification of dehydroepiandrosterone in human serum on a routine basis: development and validation of a tandem mass spectrometry method based on a surrogate analyte. Anal Bioanal Chem 410, 407–416 (2018). https://doi.org/10.1007/s00216-017-0731-x

CHARALAMPOPOULOS, I., ALEXAKI, V.-I., TSATSANIS, C., MINAS, V., DERMITZAKI, E., LASARIDIS, I., VARDOULI, L., STOURNARAS, C., MARGIORIS, A.N., CASTANAS, E. and GRAVANIS, A. (2006), Neurosteroids as Endogenous Inhibitors of Neuronal Cell Apoptosis in Aging. Annals of the New York Academy of Sciences, 1088: 139-152. https://doi.org/10.1196/annals.1366.003

Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins 101 (21) 8209-8214 https://doi.org/10.1073/pnas.030663110

Tai, S.SC., Xu, B., Welch, M.J. et al. Development and evaluation of a candidate reference measurement procedure for the determination of testosterone in human serum using isotope dilution liquid chromatography/tandem mass spectrometry. Anal Bioanal Chem 388, 1087–1094 (2007). https://doi.org/10.1007/s00216-007-1355-3

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